Sulfasalazine

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Determination of Sulfasalazine in Sulfasalazine Tablets Using Silver Nanoparticles

     Resonance light scattering (RLS) intensity of silver nanoparticles in the presence of sodium dodecylsulphate was quenched on addition of sulfasalzine. The quenching extent was shown to be proportional to the sulfasalazine concentration. Effect of different parameters such as pH, volume and kind of buffer, silver nanoparticles concentration, sodium dodecylsulphate (SDS) concentration, and w...

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Sulfasalazine-induced pulmonary disease.

We report the findings in two patients with sulfasalazine-induced pulmonary disease. The first patient developed pulmonary interstitial fibrosis after more than 4 yr of treatment for Crohn's disease. Pulmonary symptoms and chest roentgenographic and pulmonary function abnormalities gradually reversed after stopping the drug. No specific treatment was given. The second patient, who had rheumatoi...

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The imide tautomer of sulfasalazine.

The title compound, 5-[4-[(2-pyridylideneamino)sulfonyl]phenyldiazenyl]salicylic acid, C(18)H(14)N(4)O(5)S, crystallizes as the imide tautomer in the monoclinic space group P2(1)/c. In addition to an intramolecular O-H.O hydrogen bond, intermolecular O-H.O interactions link adjacent molecules into helices, which are connected by pairwise N-H.N interactions into two-dimensional hydrogen-bonded l...

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When a DMARD fails, should patients switch to sulfasalazine or add sulfasalazine to continuing leflunomide?

OBJECTIVE To evaluate the efficacy and safety of adding sulfasalazine to leflunomide treatment compared with switching to sulfasalazine alone in patients with RA with an inadequate response to leflunomide monotherapy. METHODS Patients with active RA ((DAS28) >3.2) who were enrolled in the first open label phase of the RELIEF study received leflunomide for 24 weeks. Inadequate responders then ...

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Rash and fever after sulfasalazine use.

A 28 year old Afro-Caribbean woman presented to our hospital with a three day history of an acute, diffuse, urticarial, papular rash on her trunk, limbs, and face. She also had facial swelling and fever. The mucosa and conjunctiva were not affected. Her medical history was unremarkable until a recent diagnosis of seronegative inflammatory arthritis during her second trimester of pregnancy, for ...

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ژورنال

عنوان ژورنال: Reactions Weekly

سال: 2021

ISSN: ['1179-2051', '0114-9954']

DOI: https://doi.org/10.1007/s40278-021-95978-y